In this article, OracleBio’s Senior Clinical Pathologist, Dr. Gabriele Kohnen, gives her perspective on the proposed role of tertiary lymphoid structures within the immune system and how better understanding their prevalence, cellular content and distribution may...
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Where does Cancer come from? – Cancer precursors and their terminology
In this article, OracleBio Senior Clinical Pathologist, Dr. James Going, talks about the importance of understanding where cancer comes from as we seek earlier detection and appropriate treatment.A neoplasm is a population of abnormal cells which persist and...
5 Ways Quantitative Digital Pathology Can Add Value to Immuno-Oncology R&D
Quantifying the number, type and distribution of immune cells in oncology tissue is key to obtaining a greater understanding of the actions of immunotherapies as part of immuno-oncology research. With the advent of advanced quantitative digital histopathology...
Quantification of Tumour and Stroma Cell Content within Laser Microdissection (LMD) Tissue
According to the American Cancer Society, an estimated 88,000 new cases of gynecologic cancer are diagnosed per year in the U.S., and over 29,000 American women will lose their battle with this deadly disease. Over the past 12 months, OracleBio has supported work lead...
Quantification of Dual LAG-3 and CD3 IHC-stained T Cells in Clinical Tumor Tissue using Image Analysis
The characterisation of immune cells within the tumor microenvironment and their potential impact on cancer treatment and prognosis has been the subject of intense investigation over recent years. Non-small cell lung cancer (NSCLC) patients have impaired immune...
Use of histology image analysis to aid selection of oncology xenograft models for drug development
The development of new oncology therapies is routinely supported through the use of various xenograft models. Identifying the most suitable models for use in pre-clinical oncology programmes is key to establishing a successful translational R&D strategy. The...