NAS Score & Pathologist Review
NAS score for Pre-clinical NASH models
Non-Alcoholic Steatohepatitis (NASH) is a chronic liver disease clinically characterized by hepatic steatosis, lobular inflammation and fibrosis.
In pre-clinical research, various animal models have been shown to mimic the histopathological features and stages of NASH.
The NASH/NAFLD Activity Score (NAS) is a scoring system that semi-quantitatively evaluates and grades NASH/NAFLD based on the following core histopathological features: steatosis (0-3), lobular inflammation (0-3), hepatocellular ballooning (0-2), and fibrosis (0-4).
The use of NAS scoring has been shown to be a reproducible and reliable scoring system suited for the assessment pre-clinical murine models of NASH and Liver Fibrosis.
In collaboration with one of our CRO partners, OracleBio can provide full histology and IHC services and a range of NASH/NAFLD and Fibrosis qualitative assessment read-outs to complement our quantitative image analysis data.
Figure 1. Example Hematoxylin and Eosin (H&E) Stained NASH Model Tissue