According to the American Cancer Society, an estimated 88,000 new cases of gynecologic cancer are diagnosed per year in the U.S., and over 29,000 American women will lose their battle with this deadly disease. Over the past 12 months, OracleBio has supported work lead by Dr. Tom Conrads and Dr. Nick Bateman at the Women’s Health Integrated Research Center (WHIRC) in Annandale, VA, in their research of gynaecologic cancers. Their group utilizes Laser microdissection (LMD) to enable decoupled molecular profiling analyses of tumour and non-tumor cells not otherwise possible using routine methods.
Activities between the 2 groups resulted in a joint poster presentation at the recent AACR congress in Atlanta Georgia highlighting work conducted by WHIRC postdoctoral fellow Dr. Allison Hunt, which evaluated the compositional heterogeneity of high-grade serous ovarian cancers (HGSOC) and the complex admixture of cells that comprise the tumour microenvironment. This study was conducted to demonstrate that histology combined with digital image analysis can be utilized to quantify tumour and stroma cell content within LMD-enriched regions of interest (ROI). An example of the workflow is shown below in Figure 1.