Get in touch +44 (0)141 255 1640 | firstname.lastname@example.org
Cardiovascular IHC Analysis
Cardiovascular disease covers a number of debilitating conditions including Atherosclerosis, Hypertension, Myocardial Infarction and Congestive Heart Failure. In the development of novel therapies, numerous models are utilised in which histological and immunohistochemistry methods are applied to determine drug response directly in affected tissues. At OracleBio we have extensive experience of profiling compound efficacy within histological tissue samples from pre-clinical atherosclerosis studies including ApoE KO and balloon injury models.
Customised algorithms are developed to detect cardiovascular disease read-outs including atherosclerosis and myocardial cell parameters. Example images shown left highlight the detection of atherosclerosis plaque in the aortic sinus region of the heart stained with H&E and also macrophage content via IHC in the brachiocephalic artery.
Detection of atherosclerotic plaque
Quantification of atherosclerotic plaque deposition within aortic sinus or braciocephalic artery of ApoE KO model.
Evaluation of atherosclerotic plaque content parameters including macrophage, extracellular lipid, collagen and smooth muscle cells.
Detailed analysis of myocardial hypertrophy on a cell by cell basis.
Evaluation of drug response on inflammatory cell infiltration, necrosis and angiogenesis in myocardial infarct tissue.
Changes in specific biomarker expression or cell signalling markers
Quantification of changes in vessel wall stenosis, hyperplasia and apoptosis.
Gain a detailed insight into how your drug is affecting cardiovascular disease. Understand effects on tissue pathology and specific drug associated mechanism of action within the tissue.
We can provide a service which includes atherosclerotic tissue processing and embedding, FFPE tissue sectioning, histology and IHC staining, image capture and analysis.
We can also source specific cardiovascular tissue specimens and perform histology/IHC and image analysis as part of drug target validation, drug repositioning or patient stratification studies
Click on the different category headings to find out more. You can also change some of your preferences. Note that blocking some types of cookies may impact your experience on our websites and the services we are able to offer.
Essential Website Cookies
These cookies are strictly necessary to provide you with services available through our website and to use some of its features.
We provide you with a list of stored cookies on your computer in our domain so you can check what we stored. Due to security reasons we are not able to show or modify cookies from other domains. You can check these in your browser security settings.
Google Analytics Cookies
These cookies collect information that is used either in aggregate form to help us understand how our website is being used or how effective our marketing campaigns are, or to help us customize our website and application for you in order to enhance your experience.
If you do not want that we track your visit to our site you can disable tracking in your browser here:
Other external services
We also use different external services like Google Webfonts, Google Maps, and external Video providers. Since these providers may collect personal data like your IP address we allow you to block them here. Please be aware that this might heavily reduce the functionality and appearance of our site. Changes will take effect once you reload the page.
Google Webfont Settings:
Google Map Settings:
Google reCaptcha Settings:
Vimeo and Youtube video embeds:
The following cookies are also needed - You can choose if you want to allow them: