Get in touch +44 (0)141 255 1640 | email@example.com
Immune Cell Tumor Infiltration
With the recent development of spatial analysis algorithms, it is now possible to further quantify immune cell relationships in terms of cell infiltrations at tumor/stroma margins. Concentric rings placed inside the Tumor-Stroma border at pre-determined distances, allow the quantification of immune cells within defined bands inside a tumor. This approach can help confirm the mechanism of action of therapies that are designed to increase the infiltration of immune cells into tumor from surrounding tissue.
Tumor/stroma border with FoxP3 positive nuclei (brown/green) and CD8 (pink/red) positive cells being detected
Once we receive your slides or images for evaluation, we develop a customised algorithm to address the specific question of interest. For example, to evaluate therapeutic effect on immune cell tumor infiltration from the stroma we first automatically define tumor and stroma regions of interest (ROI) across the whole tissue section. IHC stained immune cells are then quantified within each ROI before application of proximity regions at the tumor/stroma border to specifically quantify those cells infiltrating into the tumor. Example analysis and data is shown in the images to the right. We analyse each section in a consistent, detailed way to generate data which is fully representative of the staining and cellular distribution present in your tissue samples.
FoxP3 (green) and CD8 (red) tumor infiltration within 300um of tumor border
Area of specific tissue regions of interest (ROI) including Tumor, Stroma & Necrotic content across whole section.
Area of each proximity band.
Number of cells per mm2 in each proximity band.
Immune Cell Infiltration Data
Receive highly detailed data quantifying immune / inflammatory cell infiltration within defined proximity regions of tumor.
Our automated batch analysis service objectively analyses each section using the same algorithm to reduce variability and improve data quality and interpretation.
Click on the different category headings to find out more. You can also change some of your preferences. Note that blocking some types of cookies may impact your experience on our websites and the services we are able to offer.
Essential Website Cookies
These cookies are strictly necessary to provide you with services available through our website and to use some of its features.
We provide you with a list of stored cookies on your computer in our domain so you can check what we stored. Due to security reasons we are not able to show or modify cookies from other domains. You can check these in your browser security settings.
Google Analytics Cookies
These cookies collect information that is used either in aggregate form to help us understand how our website is being used or how effective our marketing campaigns are, or to help us customize our website and application for you in order to enhance your experience.
If you do not want that we track your visit to our site you can disable tracking in your browser here:
Other external services
We also use different external services like Google Webfonts, Google Maps, and external Video providers. Since these providers may collect personal data like your IP address we allow you to block them here. Please be aware that this might heavily reduce the functionality and appearance of our site. Changes will take effect once you reload the page.
Google Webfont Settings:
Google Map Settings:
Google reCaptcha Settings:
Vimeo and Youtube video embeds:
The following cookies are also needed - You can choose if you want to allow them: