providing high precision, quantitative, digital image analysis services to support pre-clinical and clinical research

Clinical Services

Quantitative Image Analysis has wide application in clinical research including, patient stratification, drug response readout, biomarker and target expression studies. OracleBio has extensive experience in performing quantitative analysis of clinical tissue samples for evaluation of biomarker expression and drug proof of mechanism read-outs. We have performed numerous clinical studies involving development of customised analysis algorithms for specific IHC and/or IF marker read-outs. Analysis is performed in a detailed and objective manner across digital whole slide tissue images to ensure data is fully representative of the staining present. We can further provide full GLP IHC staining services as well as CAP registered pathologist input for guidance on specific tissue region of interest selection. We pride ourselves on providing a professional, efficient service with excellent communication key to delivering a successful outcome.

Histopathology Image Analysis can be applied across the following clinical areas

  • Patient Stratification

    Quantification of specific tissue markers, mechanistic readouts or intercellular signalling proteins can predict drug response or disease status within specific patient populations. Histopathology image analysis allows for detailed quantification of changes in marker expression across whole tissues or within specific regions of interest (tissue subtypes) to better guide choice of drug dose or clinical population for trial inclusion.

  • Biomarker expression

    We have experience of quantifying biomarker staining in clinical trial tissue sampes. Such biomarkers can demonstrate evidence of early pharmacodynamic readouts or toxicity profiles in tissues to better guide dose setting in later stage or larger clinial trials. We also work with GLP Histology CRO partners to provide a complete histology/IHC, digital slide scanning and image analysis service.

  • Target validation

    Image analysis can be used to quantify and localise target expression in the absence and presence of drug treatment and across healthy and diseased tissue.

Contact us for more information about our Image Analysis services