In this article, we will briefly discuss different methods to detect and segment nuclei and in particular, give examples of how artificial intelligence (AI) Deep Learning (DL) methods are increasingly being applied within our organisation to streamline our image...
.
Using AI to assess Tertiary Lymphoid Structures in H&E and mIF stained Liver tissue
Following on from our previous article on Tertiary Lymphoid Structures (TLS), in which OracleBio clinical pathologist Gabriele Kohnen discussed the potential role of Tertiary Lymphoid Structures in normal and diseased tissues, this article describes some recent work...
Tertiary Lymphoid Structures and their role within the Immune System
In this article, OracleBio’s Senior Pathologist, Dr. Gabriele Kohnen, gives her perspective on the proposed role of tertiary lymphoid structures within the immune system and how better understanding their prevalence, cellular content and distribution may provide...
Where does Cancer come from? – Cancer precursors and their terminology
A neoplasm is a population of abnormal cells which persist and proliferate excessively. Almost all cell types and tissues give rise to neoplasia: epithelium, connective tissue, bone marrow, lymphoid, neural tissue &c, but nine out of 10 cancers are invasive...
Using Deep Learning to address Staining Variance across Multiplex IF images
Multiplex IF assays are highly valuable in generating data that enables a deeper understanding of cell phenotypes, their functional status, and spatial relationships within tissues across different diseases or therapeutic interventions. However, the staining of...
Appraise, Action, Adapt & Adopt – Our continuous improvements in GCP
Earlier this year, we announced that OracleBio is now conducting quantitative image analysis on clinical trial samples in accordance with Good Clinical Practices (GCP). Having recognised these standards, it is important to ensure that this high-level quality is...
Still at the Cutting Edge: Microtomy and Digital Pathology
In 2012, my friend and colleague Dr. Gabriele Kohnen salvaged three identical old microtomes from a skip (dumpster for our friends in the US!). After storing them in her garage for a decade, she gave them to me. I guessed they might date from the 1930s, but...
OracleBio’s green journey so far – Our road to sustainability
As a Glasgow-born company, we're immensely proud to see COP26 being hosted in our home city. With the Climate Change Conference in mind, it's a good time for us to reflect on our own actions and how we're helping tackle climate change as a company and as individuals....
Digital Pathology Today Podcast with John Waller
In this podcast, our Chief Operations Officer & founder, John Waller, was invited onto the hugely popular Digital Pathology Today podcast. John and the podcast host, Dr. Joseph Anderson, chat about OracleBio’s humble beginnings and our quantitative digital...
OracleBio and the INCISE collaboration project
Bowel cancer is currently the second most deadly cancer in the UK, accounting for 10% of all cancer deaths. The current screening protocol for this type of malignancy involves a colonoscopy for patients who test positive for blood in their stool. About one in three of...
Working With Multiplex Images
Imagine an image 20,000 times the file size of a standard iPhone photo... and imagine hundreds of these images having to be transferred, stored, and analysed to reveal their secrets. That's the reality and the challenge facing researchers working in the field of...
Quantitative Image Analysis and GCP: Q&A Blog
OracleBio's recent GCP implementation was driven by Clinical Operations Manager, Alison Bigley. In this blog, Alison discusses why GCP is important, the current state of play with regulatory standards in image analysis and more...What is Good Clinical Practice and why...