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In this article, we will briefly discuss different methods to detect and segment nuclei and in particular, give examples of how artificial intelligence (AI) Deep Learning (DL) methods are increasingly being applied within our organisation to streamline our image...
Following on from our previous article on Tertiary Lymphoid Structures (TLS), in which OracleBio clinical pathologist Gabriele Kohnen discussed the potential role of Tertiary Lymphoid Structures in normal and diseased tissues, this article describes some recent work...
In this article, OracleBio’s Senior Pathologist, Dr. Gabriele Kohnen, gives her perspective on the proposed role of tertiary lymphoid structures within the immune system and how better understanding their prevalence, cellular content and distribution may provide...
A neoplasm is a population of abnormal cells which persist and proliferate excessively. Almost all cell types and tissues give rise to neoplasia: epithelium, connective tissue, bone marrow, lymphoid, neural tissue &c, but nine out of 10 cancers are invasive...
Multiplex IF assays are highly valuable in generating data that enables a deeper understanding of cell phenotypes, their functional status, and spatial relationships within tissues across different diseases or therapeutic interventions. However, the staining of...
Earlier this year, we announced that OracleBio is now conducting quantitative image analysis on clinical trial samples in accordance with Good Clinical Practices (GCP). Having recognised these standards, it is important to ensure that this high-level quality is...
In 2012, my friend and colleague Dr. Gabriele Kohnen salvaged three identical old microtomes from a skip (dumpster for our friends in the US!). After storing them in her garage for a decade, she gave them to me. I guessed they might date from the 1930s, but...
As a Glasgow-born company, we're immensely proud to see COP26 being hosted in our home city. With the Climate Change Conference in mind, it's a good time for us to reflect on our own actions and how we're helping tackle climate change as a company and as individuals....
In this podcast, our Chief Operations Officer & founder, John Waller, was invited onto the hugely popular Digital Pathology Today podcast. John and the podcast host, Dr. Joseph Anderson, chat about OracleBio’s humble beginnings and our quantitative digital...
Bowel cancer is currently the second most deadly cancer in the UK, accounting for 10% of all cancer deaths. The current screening protocol for this type of malignancy involves a colonoscopy for patients who test positive for blood in their stool. About one in three of...
Imagine an image 20,000 times the file size of a standard iPhone photo... and imagine hundreds of these images having to be transferred, stored, and analysed to reveal their secrets. That's the reality and the challenge facing researchers working in the field of...
OracleBio's recent GCP implementation was driven by Clinical Operations Manager, Alison Bigley. In this blog, Alison discusses why GCP is important, the current state of play with regulatory standards in image analysis and more...What is Good Clinical Practice and why...