Quantification of Differential Fibrotic Lesions by Image Analysis in the Mouse Bleomycin Model of Pulmonary Fibrosis

OracleBio presented a poster at the American Thoracic Society Conference, which took place from the 19th to the 24th of May in Washington D.C. The poster, made in collaboration with Charles River and Grünenthal, is entitled ‘Quantification of Differential Fibrotic Lesions by Image Analysis in the Mouse Bleomycin Model of Pulmonary Fibrosis’ and is available to view or download below.

Click here to view or download the poster

Pulmonary Fibrosis Poster

The poster shows data from a study in which areas of distinct pathology in lungs from Bleomycin challenged mice were classified over a 56 day period. Whole slide digital image analysis of picrosirius red (PSR) stained lung sections was utilised to accurately assess the degree of pulmonary injury. Together with pathology review, we classified and objectively quantified two types of Bleo-induced pulmonary lesion with distinct histo-morphological characteristics.

The poster shows that digital image analysis, together with pathology review, may provide a more accurate interpretation of the development of the bleomycin-induced fibrotic lesion. This may provide a new tool to pre-clinically investigate the effect of novel therapies on more refined lesion phenotypes, which may align closer to fibrotic disease development and therapeutic responsive pathology observed in clinical pulmonary fibrosis lung tissue.

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