Correlation of Nintedanib Efficacy on Fibrotic Lesion Deposition and Lung Function within a Rat IPF Model

OracleBio data was presented on a poster at the European Respiratory Society International Congress, which took place on the 9th – 13th September 2017. The poster, produced in collaboration with Envigo, is entitled ‘Correlation of Nintedanib Efficacy on Fibrotic Lesion Deposition and Lung Function within a Rat Idiopathic Pulmonary Fibrosis (IPF) Model’ and is available to view and download below.

Click here to view or download the poster

The poster shows data from a study which aimed to assess whether decreases in lung function capacity in a bleomycin induced rat model of Idiopathic Pulmonary Fibrosis correlated with the lung fibrotic lesion area, and whether Nintedanib (NTB) treatment could attenuate these changes. The data shows a correlation between % fibrotic lesion area and decline in forced vital capacity parameters which supports the hypothesis that lung function decline is driven by increased lesion deposition. The efficacy of NTB on both of these parameters also supports the hypothesis that the efficacy of NTB is driven by its action on fibrotic lesion area rather than any anti-inflammatory effects. To find out more about the study, please contact us.

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