Quantitative Image Analysis of Fibrotic Lesion Progression in the Mouse Bleomycin Model of Pulmonary Fibrosis

OracleBio data was presented on a poster at the Keystone Symposia Injury, Inflammation and Fibrosis Conference, taking place 26th – 30th March 2017. The poster, made in collaboration with Charles River and Grünenthal, is entitled ‘Quantitative Image Analysis of Fibrotic Lesion Progression in the Mouse Bleomycin Model of Pulmonary Fibrosis’ and is provided in full below.

Click to view or download the poster

Quantitative Image Analysis of Fibrotic Lesion Progression in the Mouse Bleomycin Model of Pulmonary Fibrosis

The poster shows data from a study with the objective of classifying areas of distinct pathology in lungs from Bleo-challenged mice over a 56 day time course. To accurately assess the degree of pulmonary injury, we utilised whole slide digital image analysis of picrosirius red (PSR) stained lung sections. Together with pathology review, we classified and objectively quantified two types of Bleomycin -induced pulmonary lesion with distinct histo-morphological characteristics.

The poster concludes that digital image analysis together with pathology review may provide a more accurate interpretation of the development of the bleo-induced fibrotic lesion. This may provide a new tool to pre-clinically investigate the effect of novel therapies on more refined lesion phenotypes, which may align closer to fibrotic disease development and therapeutic responsive pathology observed in clinical fibrotic lung tissue.

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